Arbeitsgruppe Krebsforschung

 1
 

The team of Florian Grebien aims to contribute to a better understanding of the molecular mechanisms of leukemia development through the development and use of novel tools for functional evaluation of oncogenic aberrations. Our research is focused on Acute Myeloid Leukemia (AML), a cancer 2 of white blood cells that is characterized by the rapid growth of abnormal myeloid cells 3. The accumulation of aberrantly proliferating myeloid progenitor cells interferes with the production of normal blood cells 4, leading to bone marrow failure.

 

The concept of personalized treatment in modern medicine will require an improved molecular understanding of the pathological processes underlying neoplastic initiation and progression. Recent large-scale sequencing studies have revealed a high number of novel genetic lesions that may contribute to tumorigenesis. Thorough experimental validation of these newly identified mutations using standard methodologies, however, cannot keep up with the pace of continuously accelerating data generation. Therefore, the current challenge in modern biology is to adapt and develop novel tools for functional characterization of disease processes.

 

In a project funded by the European Research Council (ERC), we are employing novel cellular expression systems of AML oncoproteins in combination with cutting-edge proteomic-, genomic- and transcriptomic approaches in a robust experimental pipeline that enables the rapid characterization of effects of AML oncoprotein expression in a multilayered, global fashion. This is complemented by genome-scale functional studies to detect specific molecular vulnerabilities that are dependent on the oncogenic mutation of interest. Newly identified molecular mechanisms of mutated alleles are validated using primary patient-derived leukemic cells and translational mouse models of leukemia.

 

 

Leiter der Arbeitsgruppe Krebsforschung

Florian Grebien

Univ.-Prof. Dr.rer.nat. Florian Grebien
T +43 1 25077-4200
E-Mail an Florian Grebien senden
zur Visitenkarte  5

 

Mitarbeiter/innen der Arbeitsgruppe Krebsforschung

 
 
Elizabeth Claire Heyes

Elizabeth Claire Heyes MSc.
T +43 1 25077-4202
E-Mail an Elizabeth Claire Heyes senden
zur Visitenkarte  6

 
Theresa Humer

Theresa Humer BSc.
T +43 1 25077-4205
E-Mail an Theresa Humer senden
zur Visitenkarte  7

 
Fabio Liberante

Fabio Liberante PhD.
T +43 1 25077-4207
E-Mail an Fabio Liberante senden
zur Visitenkarte  8

 
Gabriele Manhart

Dipl.-Ing. Gabriele Manhart
T +43 1 25077-4205
E-Mail an Gabriele Manhart senden
zur Visitenkarte  9

 
Torben Redmer

Dr.rer.nat. Torben Redmer
T +43 1 25077-4213
E-Mail an Torben Redmer senden
zur Visitenkarte  10

 
Luisa Schmidt

Mag.rer.nat. Luisa Schmidt
T +43 1 25077-4202
E-Mail an Luisa Schmidt senden
zur Visitenkarte  11

 
Johannes Schmöllerl

Johannes Schmöllerl MSc. BSc.
T +43 1 25077-4202
E-Mail an Johannes Schmöllerl senden
zur Visitenkarte  12

 
Stefan Terlecki-Zaniewicz

Stefan Terlecki-Zaniewicz MSc.
T +43 1 25077-4202
E-Mail an Stefan Terlecki-Zaniewicz senden
zur Visitenkarte  13

 
Selina Tröster

MRes Selina Tröster
T +43 1 25077-4202
E-Mail an Selina Tröster senden
zur Visitenkarte  14

  

Öffnungszeiten

Montag bis Freitag:
08:00-15:30 Uhr

Sekretariat
E-Mail an Manuela Thullner senden

+43-1-25077-4201

Sekretariatszeiten:
Montag - Freitag
8:00 - 12:00 und 13:30 - 15:00


 

Kontakt

Institut für Medizinische Biochemie
1210 Wien, Veterinärplatz 1

T +43 1 25077-4201
F +43 1 25077-4290
E-Mail an Institut für Med. Biochemie senden

Anreise zur Vetmeduni Vienna 15