Colon Cancer

We are also studying normal and abnormal gastro intestinal tract function and colorectal carcinoma development and progressoion in association with JAK-STAT1/3/5 signaling. Current work in collaboration with international research groups is mainly addressing regulation of the tight junction through cytokine signaling in epithelial cells and intestinal epithelial stem cells. In addition, the RM lab is involved in therapeutic intervention studies for chronic inflammatory processes and colorectal cancer prevention. We are active in an international collaboration project on NIH or DOD grants with the group of Prof. Xiaonan Han, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

Lower median survival in Colon cancer patients with concomitant absence of nuclear STAT1 and STAT3. Examples of patient TMAs with nuclear STAT1 and STAT3 staining, showing different levels of STAT expression. a. Immunohistochemical staining was scored by two board certified pathologists as negative (score 0), weak (score 1), moderate (score 2) or strong (score 3). b. Patients show reduced survival upon concomitant absence of nuclear STAT1 and STAT3.
Lower median survival in Colon cancer patients with concomitant absence of nuclear STAT1 and STAT3 1