“PIG-MI-MUC” – Understanding and modulating the bidirectional crosstalk between gut microbiome and gut mucosal functionality in pigs at weaning and post-weaning

When piglets are weaned, one of the biggest dietary changes is the complete lack of sow milk, which has drastic consequences for the gut microbiome composition. The aim in the project are “PIG-MI-MUC” is to thoroughly characterize alterations in the small and large intestinal microbiome from milk-oriented to a plant-oriented microbiome in composition, metagenomes and metabolites during weaning. In addition, also the gut mucosal response with regard to barrier function and receptor-mediated recognition in the small and large intestine is investigated during the weaning transition to a plant-oriented microbiome. Further aim of this project area is to discover microbial and host analyte profiles in intestinal digesta, feces, urine and blood with key roles in the porcine gut mucosal networking that predict the gut homeostatic condition in weaned pigs. In this project area feeding concepts that boost the establishment of a robust gut microbiome during the suckling phase and smoothen the transition from the milk-oriented to the plant-oriented gut microbiome and host mucosa after weaning will be investigated as well.

 

Impressions from the project PIG-MI-MUC

 
Suckling piglets with sow (Picture ©Julia Vötterl)
 1
Sow with piglets during feeding (Picture ©Julia Vötterl)
 2
 
Suckling piglets (Picture ©Frederike Lerch)
 3
Piglets in their nest (Picture ©Frederike Lerch)
 4
 
Piglets drinking milk (Picture ©Frederike Lerch)
 5
Weaned piglets (Foto ©Frederike Lerch)
 6
  

Publications

List of all publications from the Unit Nutritional Physiology    Link to VetDoc 7

Publications of individual staff members                             Link to VetDoc 8