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Genomes sequences, both from closely related species and from individuals of the same species, are increasingly available. These large amounts of data offer a great opportunity to study speciation and the evolutionary history of populations, provided we can properly model the process of evolution within and between species simultaneously. Our group focuses on the development of computational methods to the investigate adaptation at different time-scales ranging from a few generations in experimental evolution data to studies of population demography to phylogenetic analysis of multiple species.