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Veterinärmedizinische Universität Wien

Christiane Riedel

The main focus of my research is the analysis of virus architecture and dynamics of infection processes, employing cryo electron tomography and subtomogram averaging, fluorescence microscopy as well as standard molecular biology techniques. Projects include the structure of pestivirus particles, dynamics and structural changes during pestiviral host cell entry and the structure of the rabies virus ribonucleoprotein complex. If you are interested in these areas of research and would like to get in touch, just write an email.

Open positions:

We currently do not have any openings. 

Projects:

FWF-funded project: Deciphering BVDV entry by targeted functional genomics

EU HORIZON funded project: NEXT GENERATION VACCINES AND DIAGNOSTICS TO PREVENT LIVESTOCK REPRODUCTIVE DISEASES OF WORLDWIDE IMPACT

 

Latest Publications:

ADAM17 Is an Essential Factor for the Infection of Bovine Cells with Pestiviruses

Discovery of a phylogenetically distinct poxvirus in diseased Crocodilurus amazonicus (family Teiidae). 

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization.

Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells

 

Full publication list

 

 

Figure from our latest publication in Scientific Reports, "CryoEM structure of rabies virus RNP" (click photo to link to manuscript)

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Figure from our latest publication in Scientific Reports, "CryoEM structure of rabies virus RNP" (click photo to link to manuscript)

(C) Confocal Z-stack of fluorescent micrographs through BVDVE2_fluoinfected MDBK cells 48 h after infection. Scale bar represents 5 µm. (D) Cryo electron micrographs of BVDVE2_fluo infected cells 48 h after infection. Arrow indicates an intracellular virus particle. Scale bars from left to right represent 50 µm, 500 nm and 50 nm. modified from Riedel et al 2019 (click photo for link to manuscript).

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(C) Confocal Z-stack of fluorescent micrographs through BVDVE2_fluoinfected MDBK cells 48 h after infection. Scale bar represents 5 µm. (D) Cryo electron micrographs of BVDVE2_fluo infected cells 48 h after infection. Arrow indicates an intracellular virus particle. Scale bars from left to right represent 50 µm, 500 nm and 50 nm. modified from Riedel et al 2019 (click photo for link to manuscript).

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Flurophore labelled BVDV particles (red) on the surface of SK6 cells expressing flurophore labelled, bovine CD46. Scale bar = 0.9µm. Unpublished data.

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