Computational Medicine (COME) at the University of Veterinary Medicine, Vienna, was established in 2022 to integrate advanced computational methods with veterinary science and agricultural research. Led by Peter M. Roth, COME was intended to develop theoretical machine learning algorithms alongside practical, data-driven solutions for challenges in animal health and crop management. Combining methodological research with real-world applications, the unit advanced animal welfare and agricultural sustainability, while also working to bring these aspects into modern teaching. Starting from scratch, the team grew to more than ten members by the end of 2023. Although it became clear in early 2025 that the unit would not continue in its current form and no new projects could be started, COME will remain a key player in computational veterinary medicine.