Research within the unit focuses on elucidating the biological functions and regulatory mechanisms of the ERBB receptor system under physiological homeostasis as well as in the pathogenesis of diseases affecting specific tissues and organ systems. The ERBB receptor network is investigated using a broad spectrum of experimental platforms, including advanced in vitro models such as 3D bioprinted tissues, organoids, and organ-on-a-chip systems, as well as in vivo approaches employing genetically engineered mouse models and large-animal models.

A dedicated research group focuses on the refinement of the 3Rs principles (Replacement, Reduction, and Refinement) in mouse husbandry and experimental procedures, with the objective of developing and implementing innovative strategies to enhance animal welfare and improve experimental quality.

Using advanced genome engineering and assisted reproductive technologies, the unit provides comprehensive services for the design and generation of genetically modified mouse models. Furthermore, mouse strains are preserved through cryopreservation and can be efficiently rederived on demand using in vitro fertilization and related reproductive technologies.

The unit also functions as the Austrian node of the European Mouse Mutant Archive (EMMA), contributing to the long-term preservation, quality-controlled archiving, and international distribution of valuable mouse models. Through this infrastructure, genetically altered mouse lines are made accessible to the global scientific community, thereby promoting reproducibility, resource sharing, and collaborative biomedical research.