Indications for Clonality Testing

• Samples with ambiguous results in cytology, histology and/or Flow cytometry (FC)

• Early stages are difficult to distinguish from lymphoid hyperplasia – confirmation

• Effusions with large numbers of small, mature-appearing lymphocytes

• FNA or cavity fluid – detecting small numbers of atypical lymphocytes

• Adjunct tool in the characterization of IBD

• Identification of monoclonal lymphocytic populations, because FC cannot identify if a population is mono-, oligo-, or polyclonal

• Completion of the diagnosis lymphoma after cytology, clinical exam, histology and immunophenotyping