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Clonality Testing of Lymphocytes (PARR PCR Assay)

Indications for Clonality Testing

  • Samples with ambiguous results in cytology, histology and/or Flow cytometry (FC)

  • Early stages are difficult to distinguish from lymphoid hyperplasia – confirmation

  • Effusions with large numbers of small, mature-appearing lymphocytes

  • FNA or cavity fluid – detecting small numbers of atypical lymphocytes

  • Adjunct tool in the characterization of IBD

  • Identification of monoclonal lymphocytic populations, because FC cannot identify if a population is mono-, oligo-, or polyclonal

  • Completion of the diagnosis lymphoma after cytology, clinical exam, histology and immunophenotyping

Work flow for Clonality Testing

Selected References

  • Hammer et al. Vet Comp Oncol (2016) doi: 10.1111/vco.12277
  • Greß et al. Res Vet Sci 107 (2016) 261-266.
  • Keller et al. Vet Pathol 53 (2016) 711-725.
  • Rütgen et al. Vet Clin Pathol. 45 (2016) 172-8.
  • Rütgen et al. Vet Clin Pathol. 44 (2015) 58-69.
  • Rütgen et al. Leuk Res. 34 (2010) 932-8.