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Clonality Testing of Lymphocytes (PARR PCR Assay)

Indications for Clonality Testing

  • Samples with ambiguous results in cytology, histology and/or Flow cytometry (FC)

  • Early stages are difficult to distinguish from lymphoid hyperplasia – confirmation

  • Effusions with large numbers of small, mature-appearing lymphocytes

  • FNA or cavity fluid – detecting small numbers of atypical lymphocytes

  • Adjunct tool in the characterization of IBD

  • Identification of monoclonal lymphocytic populations, because FC cannot identify if a population is mono-, oligo-, or polyclonal

  • Completion of the diagnosis lymphoma after cytology, clinical exam, histology and immunophenotyping

Work flow for Clonality Testing

Selected References

  • Welter et al. Vet Immunol Immunopathol 242 (2021) 110350.
  • Unterkreuter et al. Res Vet Sci 135(2021) 511-516.
  • Luckschander-Zeller et al. Vet Immunol Immunopathol 214 (2019) 109893.
  • Hammer et al. Vet Comp Oncol 15 (2017) 1354-1369.
  • Greß et al. Res Vet Sci 107 (2016) 261-266.
  • Keller et al. Vet Pathol 53 (2016) 711-725.
  • Rütgen et al. Vet Clin Pathol. 45 (2016) 172-178.
  • Rütgen et al. Vet Clin Pathol. 44 (2015) 58-69.
  • Rütgen et al. Leuk Res. 34 (2010) 932-938.

Sample Submission

Samples have to be shipped to the Central Laboratory (Clinical Pathology Unit) together with the sample submission form.

Detailed information about sample submission can be found by following this LINK.

Sample submission guide

Sample submission form


Dr. Sabine Hammer
Institute of Immunology
Dr. Barbara Rütgen
Clinical Pathology Unit