The research group investigates the diverse functions and biological roles of the ERBB receptor family in tissue homeostasis and disease across different organs. To study the ERBB signaling network, we employ a broad range of in vitro models, including cell cultures, organoids, 3D tissue models, and organ-on-a-chip systems, as well as in vivo models, primarily genetically engineered mouse models. A comprehensive understanding of ERBB receptor biology is essential for developing improved therapeutic strategies for diseases in which ERBB signaling plays a central role. The ERBB receptor family belongs to the receptor tyrosine kinase (RTK) superfamily and is expressed in a wide range of tissues and organs. It comprises four members: epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 (HER2/neu), ERBB3 (HER3), and ERBB4 (HER4). Eleven ligands have been identified that bind to ERBB receptors and induce receptor homo- or heterodimerization. Dimerization triggers autophosphorylation of the intracellular kinase domains, leading to activation of multiple downstream signaling pathways that regulate cell proliferation, differentiation, survival, and migration.