Overall project coordination: Dr. Gabrielle Stalder & Dr. Friederike Pohlin
Respiratory depression induced by highly potent opioids such as etorphine remains a major challenge in wildlife anesthesia. While etorphine provides rapid and reliable immobilization, the associated respiratory depression leads to hypoxemia, hypercapnia, and acidosis. Etorphine is thought to cause respiratory impairment via activation of mu-receptors in the brainstem and induces a sympathetic stress response leading to pulmonary hypertension, among others.
Serotonin agonists, and in particular 5-HT4 receptor agonists, reduce centrally mediated opioid-induced respiratory depression because 5-HT4 receptors are co-expressed with mu-opioid receptors on brainstem respiratory neurons but have opposite effects. The 5-HT4 receptor agonist BIMU-8 has shown promise in early studies to alleviate opioid-induced respiratory depression without compromising sedation or analgesia. It is also believed that peripherally acting alpha-2 adrenoceptor antagonists may reduce some of the adverse effects of an etorphine-induced sympathetic response, particularly pulmonary hypertension.
In this study, we investigate whether BIMU-8 and the peripherally acting alpha-2 antagonist vatinoxan can attenuate or reverse etorphine-induced respiratory depression without compromising sedation or leading to additional undesirable side effects.
15 April 22-14 April 27
The Scholarship in Commemoration of Her Royal Heighness Princess Chulabhorn´s 60th Birthday Anniversary
Further staff at FIWI: Rattanathanya Hathaipat and Dr. Johanna Painer-Gigler
Further participating institutions at Vetmeduni
University Clinic for small animals, Clinical unit for anesthesiology and perioperative intensive medicine
(Further) Project partners
Prof. Leith Meyer, University of Pretoria, Pretoria, South Africa
Priv.-Doz. Dipl.-Ing. Dr. Stefan Böhmdorfer,University of Natural Resources and Life Sciences, Vienna (BOKU), Austria
Marja Raekallio DVM, PhD, University of Helsinki, Finland
Sponsored by the Chulabhorn Royal Academy, Bangkok, Thailand