Our research explores how cells communicate to coordinate immune responses and protect the body against infection. We focus on interferons and the JAK/STAT signalling pathway, key regulators of immunity that help the body respond to pathogens while maintaining tissue health. Dysregulation of these signalling networks can cause inflammatory and autoimmune diseases. By investigating how these signalling networks control immune responses in different organs and cell types, we aim to uncover the mechanisms that enable effective defence against viruses, bacteria, and fungi while preventing excessive inflammation and tissue damage. To address these questions, we combine advanced technologies, including high-dimensional flow cytometry, single-cell analyses, microscopy, proteomics, and experimental models of infection. Our goal is to advance our understanding of immune regulation and lay the foundation for new therapeutic approaches to infectious, inflammatory, and immune-mediated diseases.