Cell type-specific functions of STAT1 and its Isoforms in Antimicrobial Immunity. STAT1 is a central regulator of antimicrobial immunity, yet how its functions differ between cell types and its isoforms remains poorly understood. We investigate how STAT1 controls transcriptional programs in macrophages, fibroblasts, and T cells during infection. By defining the cell type-specific activities of STAT1 isoforms, we aim to uncover mechanisms that determine protective immunity versus immunopathology and reveal fundamental principles of host defence. 

Infection-Induced Extramedullary Haematopoiesis. Infection rapidly reshapes haematopoiesis to meet the demand for immune effector cells. We study how infectious cues trigger emergency blood cell production outside the bone marrow, particularly in the spleen, and how this process is tailored to different pathogens. Understanding how extramedullary haematopoiesis is regulated will reveal how systemic immunity adapts to microbial challenge. 

TYK2 in Antifungal Host Defence. TYK2 integrates cytokine signalling pathways that are essential for antifungal immunity, but its tissue-specific functions remain incompletely understood. We investigate how TYK2 coordinates innate and adaptive immune responses at barrier surfaces and during systemic infection. These studies will define key mechanisms of antifungal host defence and identify pathways that could be targeted to enhance protective immunity. 

Type I Interferons in Tissue Homeostasis and Immunity to Infections. Interferon-α subtypes and interferon-β activate the same receptor and signalling pathways, yet increasing evidence suggests they exert distinct biological functions. We investigate how these type I interferons regulate immune and tissue responses during viral and bacterial infections, and whether they make unique contributions to host defence and tissue homeostasis. These studies aim to refine our understanding of type I interferon biology in infection and inflammation.