I am a Research Scientist in Kidney Physiology and Kidney Disease with a focus on basic and translational research in acute and chronic kidney injury.

During my doctoral program in natural sciences / biophysics at the Johannes Kepler University Linz I worked in the Rainer Oberbauer lab (www.meduniwien.ac.at/nephrogene), and focused on genetic and clinical epidemiology in kidney disease. In 2010, I graduated with a doctoral degree in natural sciences and continued my research in the Oberbauer lab. For this work, I was selected for the prestigious ÖGN Award of the Austrian Society of Nephrology and talent award from the federal state Upper Austria. From 2014-2017, I received formal research training in basic science in kidney disease, repair and regeneration medicine in the Joseph V. Bonventre lab at the Brigham and Women’s hospital, Harvard Medical School, Boston, Massachusetts funded by a Marie Curie International Outgoing Fellowship. After that, I spent several month in the laboratory of Dr. Lothar Hennighausen, NIDDK, National Institute of Health, Bethesda, Maryland, USA receiving additional training in epigenetic research. Since 2017, I am Project leader at the University of Veterinary Medicine, Vienna.

ORCID link: https://orcid.org/0000-0002-0230-9349 1

Top 10 Publications:

1.      Jankowski J, Lee HK, Wilflingseder J, and Hennighausen L. Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules. bioRxiv. 2021.

2.      Wilflingseder J, Willi M, Lee HK, Olauson H, Jankowski J, Ichimura T, et al. Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. Nat Commun. 2020;11(1):3383.

3.      Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, et al. Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018;29(6):1690-705.

4.      Wilflingseder J, Jelencsics K, Bergmeister H, Sunzenauer J, Regele H, Eskandary F, et al. miR-182-5p Inhibition Ameliorates Ischemic Acute Kidney Injury. Am J Pathol. 2017;187(1):70-9.

5.      Wilflingseder J, Sunzenauer J, Toronyi E, Heinzel A, Kainz A, Mayer B, et al. Molecular pathogenesis of post-transplant acute kidney injury: assessment of whole-genome mRNA and miRNA profiles. PLoS One. 2014;9(8):e104164.

6.      Wilflingseder J, Regele H, Perco P, Kainz A, Soleiman A, Mühlbacher F, et al. miRNA profiling discriminates types of rejection and injury in human renal allografts. Transplantation. 2013;95(6):835-41.

7.      Wilflingseder J, Kainz A, Mühlberger I, Perco P, Langer R, Kristo I, et al. Impaired metabolism in donor kidney grafts after steroid pretreatment. Transpl Int. 2010;23(8):796-804.

8.      Kainz A, Wilflingseder J, Mitterbauer C, Haller M, Burghuber C, Perco P, et al. Steroid pretreatment of organ donors to prevent postischemic renal allograft failure: a randomized, controlled trial. Ann Intern Med. 2010;153(4):222-30.

9.      Wilflingseder J, Perco P, Kainz A, Schwarz C, Korbély R, Mayer B, et al. Biocompatibility of peritoneal dialysis solutions determined by genomics of human leucocytes: a cross-over study. NDT Plus. 2009;2(6):510-2.

10.   Wilflingseder J, Kainz A, Perco P, Korbély R, Mayer B, and Oberbauer R. Molecular predictors for anaemia after kidney transplantation. Nephrol Dial Transplant. 2009;24(3):1015-23.

  

Contact

University of Veterinary Medicine Vienna (Vetmeduni Vienna)
Veterinärplatz 1
A-1210 Vienna, Austria

Unit for Physiology, Pathophysiology and
Experimental Endocrinology
Building HA, Ground Floor

Office & Administrative Support,

Irene Nefischer:

+43-1-25077-4551
Irene.Nefischer(at)vetmeduni.ac.at

Mo-Do 9-13h