The ESR spectroscopy was already employed in our lab for following applications:
- Detection of oxygen radicals in cell culture models5,6
- Detection of vitamin c radicals, transferrin, ceruloplasmin and NO (EDRF) in blood and plasma7
- Characterization of mitochondrial electron carriers8,9
- Measurement of membrane fluidity of lipid membranes10
- Elucidation of cytostatic transition metal complexes11
Other possible applications are the detection of irradiated food, aging of beer, monitoring of mineral oil degradation, antioxidant properties of food, monitoring of asbestos redox activity and many other fields.
1. L. Monzote, M. Garcia, J. Pastor, L. Gil, R. Scull, L. Maes, P. Cos, and L. Gille.
Essential oil from Chenopodium ambrosioides and main components: Activity against Leishmania, their mitochondria and other microorganisms. Exp.Parasitol. 136:20-26, 2014.
2. J. Gruber, K. Staniek, C. Krewenka, R. Moldzio, A. Patel, S. Bohmdorfer, T. Rosenau, and L. Gille.
Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. Bioorg.Med.Chem. 22 (2):684-691, 2014.
3. J. Pastor, M. Garcia, S. Steinbauer, W. N. Setzer, R. Scull, L. Gille, and L. Monzote.
Combinations of ascaridole, carvacrol, and caryophyllene oxide against Leishmania. Acta Tropica 145:31-38, 2015.
4. L. M. Fidalgo and L. Gille.
Mitochondria and trypanosomatids: targets and drugs. Pharm.Res. 28 (11):2758-2770, 2011.
5. A. Haschemi, P. Kosma, L. Gille, C. R. Evans, C. F. Burant, P. Starkl, B. Knapp, R. Haas, J. A. Schmid, C. Jandl, S. Amir, G. Lubec, J. Park, H. Esterbauer, M. Bilban, L. Brizuela, J. A. Pospisilik, L. E. Otterbein, and O. Wagner.
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 15 (6):813-826, 2012.
6. W. Warsch, E. Grundschober, A. Berger, L. Gille, S. Cerny-Reiterer, A. S. Tigan, A. Hoelbl-Kovacic, P. Valent, R. Moriggl, and V. Sexl.
STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia. Oncotarget 3 (12):1669-1687, 2012.
7. L. Gille, M. Kleiter, M. Willmann, and H. Nohl.
Paramagnetic species in the plasma of dogs with lymphoma prior to and after treatment with doxorubicin. An ESR study. Biochem.Pharmacol. 64 (12):1737-1744, 2002.
8. H. Nohl, L. Gille, and A. V. Kozlov.
Antioxidant-derived prooxidant formation from ubiquinol. Free Radic.Biol.Med. 25 (6):666-675, 1998.
9. A. Müllebner, A. Patel, W. Stamberg, K. Staniek, T. Rosenau, T. Netscher, and L. Gille.
Modulation of the mitochondrial cytochrome bc1 complex activity by chromanols and related compounds. Chem.Res.Toxicol. 23 (1):193-202, 2010.
10. E. A. Malingriaux, A. Ruprecht, L. Gille, O. Jovanovic, P. Jezek, M. Jaburek, and E. E. Pohl.
Fatty acids are key in 4-hydroxy-2-nonenal-mediated activation of uncoupling proteins 1 and 2. Plos One 8 (10):e77786, 2013.
11. C. R. Kowol, P. Heffeter, W. Miklos, L. Gille, R. Trondl, L. Cappellacci, W. Berger, and B. K. Keppler.
Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds. J.Biol.Inorg.Chem. 17 (3):409-423, 2012.